PYC Therapeutics Limited (ASX: PYC) - ETF Exposure

Current share price for PYC : $2.820 0.09 (3.09%)⁺

PYC Therapeutics (PYC) is an ASX-listed company and is held by a number of exchange traded funds (ETFs). It is a clinical-stage biotechnology company creating a new generation of RNA therapies to change the lives of patients with genetic diseases. The Company utilises its proprietary drug delivery platform to enhance the potency of precision medicines within the rapidly growing and commercially proven RNA therapeutic class.

PYC General Information ⁺

ASX Code	PYC
Website	N/A
Industry/Sector	Biotechnology
Market Cap ($M)	2,773
PYC Share Price	$2.820
Day High	$2.870
Day Low	$2.800
Last Close	$2.910
PYC Share Price Movement	$0.09 ( 3.09% )

Prices as at 16:40, 25 Sep 2026

⁺Security prices are delayed by at least 20 minutes and are indicative only.

Already own an Australian ETF? You may already have meaningful exposure to PYC

As a significant Australian company by market capitalisation, PYC is held across 5 ETFs spanning strategies that include biotechnology exposure . Its weighting in those funds means performance can have an outsized influence - when PYC moves, funds like ISO, SSO, VSO, A300 and VAS that hold it can move with it.

For more concentrated exposure, ETFs such as ISO (iShares S&P/ASX Small Ordinaries ETF Index Fund) allocate about 0.7% to PYC , while the average exposure across all 5 ETFs that hold it is around 0.3% .

Top ETF holdings

iShares S&P/ASX Small Ordinaries ETF Index Fund (ISO) ~ 0.7%
State Street SPDR S&P/ASX Small Ordinaries ETF (SSO) ~ 0.7%
Vanguard MSCI Australian Small Companies Index ETF (VSO) ~ 0.2%
Global X Australia 300 ETF (A300) ~ 0.1%
Vanguard Australian Shares Index ETF (VAS) ~ 0%

Last updated: ETF data and holdings as at 25 September 2026

Own PYC directly or through an ETF?

How does holding PYC Therapeutics Limited (PYC) shares directly compare to ETFs that include it?

	PYC Direct	ISO ASX	SSO ASX	VSO ASX	A300 ASX	VAS ASX
Holdings	1 company	218 holdings	218 holdings	203 holdings	309 holdings	331 holdings
PYC Weight	100%	0.7%	0.7%	0.2%	0.1%	0%
Diversification	Single Stock	Broad	Broad	Broad	Broad	Broad
Annual Cost	Brokerage only	0.55% p.a.	0.5% p.a.	0.3% p.a.	0.03% p.a.	0.07% p.a.
Approx. Yield	0%	4.36%	9.3%	4.83%	3.04%	4.18%
Star Ratings	-

Yields and costs are approximate. ETF yields reflect the fund's dividend distributions, not PYC's direct yield. Annual cost uses each ETF's MER.

PYC Exposure on $10,000 investment

How a $10,000 investment in PYC Therapeutics Limited (PYC) one week ago compares with ETFs that hold it.

Security	Investment type	Current price	7-day price movement	Dollar change	Value today
PYC Therapeutics Limited (PYC)	Direct share	$2.820	5.62%	+$562	$10,562
iShares S&P/ASX Small Ordinaries ETF Index Fund (ISO)	Equity - Australia Small/Mid Cap	$5.010	-1.18%	-$118	$9,882
State Street SPDR S&P/ASX Small Ordinaries ETF (SSO)	Equity - Australia Small/Mid Cap	$14.420	-1.37%	-$137	$9,863
Vanguard MSCI Australian Small Companies Index ETF (VSO)	Equity - Australia Small/Mid Cap	$72.330	-1.20%	-$120	$9,880
Global X Australia 300 ETF (A300)	Equity - Australia	$50.990	-0.76%	-$76	$9,924
Vanguard Australian Shares Index ETF (VAS)	Equity - Australia	$108.670	-0.64%	-$64	$9,936

Assumes $10,000 invested 7 days ago. Figures are based on price movement only and exclude distributions, fees and brokerage.

PYC Therapeutics Limited (PYC) ETFs

5 ETFs hold PYC Therapeutics Limited (PYC).

ETF	PYC Weight	MER	Yield
iShares S&P/ASX Small Ordinaries ETF Index Fund (ISO)	0.7%	0.55%	4.36%
State Street SPDR S&P/ASX Small Ordinaries ETF (SSO)	0.7%	0.5%	9.3%
Vanguard MSCI Australian Small Companies Index ETF (VSO)	0.2%	0.3%	4.83%
Global X Australia 300 ETF (A300)	0.1%	0.03%	3.04%
Vanguard Australian Shares Index ETF (VAS)	0%	0.07%	4.18%

PYC Therapeutics Limited (PYC) Upcoming Dividends & Yields

Distribution Type	Dividend	Franking	Ex-dividend date	Payment date	Current Price⁺	Price 7D Avg	Dividend Yield

See all dividends from PYC Therapeutics Limited (PYC) or use our Upcoming Dividends tool to search for dividends across all ASX-listed securities.

PYC Therapeutics Limited (PYC) price-sensitive announcements

PYC - Quarterly Activities/Appendix 4C Cash Flow Report

PYC Therapeutics Limited, a clinical-stage biotechnology company based in Australia, relea

PYC Therapeutics Limited (PYC)
29 Jul 2026 | 8:45 AM

PYC - PKD - Safety Committee Approves Dose Escalation

PYC Therapeutics Limited, a precision medicine company, announced that the Safety Review C

PYC Therapeutics Limited (PYC)
22 Jul 2026 | 8:20 AM

PYC - ADOA Program Update

PYC Therapeutics Limited, an Australian precision medicine company, announced significant

PYC Therapeutics Limited (PYC)
21 Jul 2026 | 8:32 AM

PYC - PKD - Initiation of Multiple Dose Clinical Trial

PYC Therapeutics Limited has initiated a Phase 1b Multiple Ascending Dose (MAD) clinical t

PYC Therapeutics Limited (PYC)
7 May 2026 | 9:03 AM

PYC Therapeutics Limited (PYC) Recent ASX Announcements

Company	Sector	Market Cap ($m)	Headline	Release date/time⁺	Price at release⁺	Current price⁺	Gain/Loss
PYC Therapeutics Limited (PYC) ORDINARY FULLY PAID	Health Care	$2,773	PKD - First Patient Dosed in OLE Study	11 Sep 2026 8:25AM	$2.320	$2.820	risen by 21.55%
PYC Therapeutics Limited (PYC) ORDINARY FULLY PAID	Health Care	$2,773	S&P DJI Announces September 2026 Quarterly Rebalance	4 Sep 2026 5:10PM	$2.490	$2.820	risen by 13.25%
PYC Therapeutics Limited (PYC) ORDINARY FULLY PAID	Health Care	$2,773	Investor Webinar Presentation Q3 2026	4 Sep 2026 8:30AM	$2.570	$2.820	risen by 9.73%
PYC Therapeutics Limited (PYC) ORDINARY FULLY PAID	Health Care	$2,773	ADOA Program - Data Presentation	3 Sep 2026 8:21AM	$2.430	$2.820	risen by 16.05%
PYC Therapeutics Limited (PYC) ORDINARY FULLY PAID	Health Care	$2,773	Ceasing to be a substantial holder	2 Sep 2026 3:52PM	$2.405	$2.820	risen by 17.26%
PYC Therapeutics Limited (PYC) ORDINARY FULLY PAID	Health Care	$2,773	PKD - Presentation of Clinical Safety Data	31 Aug 2026 8:10AM	$2.250	$2.820	risen by 25.33%

PYC Financial Summary

Year to Jun	NPAT	EPS	EPS chg (%)	Yield (%)	Franking (%)
2026A	-$43.77	-$5.90	-39.70%	0.00%	0.0%
2025A	-$51.01	-$9.80	5.50%	0.00%	0.0%
2024A	-$38.11	-$9.30	36.70%	0.00%	0.0%

PYC Peer Comparison

Company	Mkt Cap	EPS Growth (%)			P/E (%)			Dividend Yield (%)
Company	Mkt Cap	2024 A	2025 A	2026 A	2024 A	2025 A	2026 A	2024 A	2025 A	2026 A
CSL Limited (CSL)	$85,957M	0.7309	-0.4440	0.0545	11.0969	19.9585	18.9263	2.37%	2.32%	2.40%
Clinuvel Pharmaceuticals Limited (CUV)	$417M	-0.0696	-0.0719	0.0242	12.3653	13.3226	13.0079	0.61%	0.61%	0.61%
Mesoblast Limited (MSB)	$2,844M	-0.4380	0.0000	0.0000	0.0000	0.0000	347.6190	0.00%	0.00%	0.00%
PYC Therapeutics Limited (PYC)	$2,862M	-0.3971	0.0000	0.0000	0.0000	0.0000	0.0000	0.00%	0.00%	0.00%
Telix Pharmaceuticals Limited (TLX)	$5,350M	-1.3893	0.0000	-0.2777	0.0000	174.1150	241.0413	0.00%	0.00%	0.00%

PYC Directors

Name	Position	Start Date
Dr Rohan Hockings	Chief Executive Officer, Managing Director	30 Nov 2018
Mr Peter John Coleman	Non-Executive Chairman, Non-Executive Director	18 Nov 2025
Professor Ian Jeffrey Constable	Non-Executive Director	21 Sep 2025

PYC Therapeutics Limited (PYC) Changes in Directors' Interest & Trades

Date of change	Director	Buy/Sell	Security Type	Qty	Trade Price	Value
24 Mar 2026	HOCKINGS, Rohan	Buy	Direct Shares	82,550	$1.210	$99,883.000
6 Mar 2026	HOCKINGS, Rohan	Issued	Direct Shares	80,010	$1.500	$120,015.000
6 Mar 2026	CONSTABLE, Ian	Issued	Indirect Shares	123,000	$1.500	$184,500.000

See all changes in directors' interest & trades for PYC Therapeutics Limited (PYC) or use our Changes in directors' interest tool to search for changes & trades across all ASX-listed securities.

PYC Management

Name	Position
Stephen Ledger	Joint Company Secretary
Jonathan Riley	Joint Company Secretary

PYC Substantial Shareholders

Under ASX rules large investors and investment funds must disclose when they own more than a 5% stake in PYC Therapeutics Limited (PYC). However, you won't necessarily see their names in the company’s annual report, as many trade under nominee names. These shareholders are obliged to provide ongoing substantial notices relating to any change of 1% or more.

Holding	Name
92,818,753 (9.44%)	RA Capital Healthcare Fund GP, LLC
84,578,385 (8.60%)	Australian Land Pty Ltd

PYC Calendar of Events

Date	Event
27 August 2027	Report (Annual)
27 August 2027	Report (Prelim)
22 February 2027	Report (Interim)

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