The Australian stock market lost more than 0.5% at the open as concerns about a possible military strike on Syria cut into Wall Street's early gains.
At the 1015 AEST official market open, the benchmark S&P/ASX200 index lost 0.69% to 5,161 points, while the broader All Ordinaries index fell 0.64% to 5,155.5 points.
In economic news on Wednesday, the Australian Bureau of Statistics releases national accounts figures, including gross domestic product, for the June quarter, along with overseas arrivals and departures numbers for July.
Meanwhile, the Australian Industry Group/Commonwealth Bank Australian Performance of Services Index (PSI) for August was released, with the survey showing the sector experienced its lowest level of activity since the GFC.
No major equities news is expected.
In Australia, the market on Tuesday edged higher despite disappointing figures on retail sales and Australia's widening current account deficit.
The benchmark S&P/ASX200 index gained 8.3 points, or 0.16%, to 5,196.6 points.
The broader All Ordinaries index added 10.9 points, or 0.21%, higher to 5,188.9 points.